Tachykinin receptor

 ( G Protein-coupled Receptors ) 

There are three known mammalian tachykinin receptors termed NK₁, NK₂ and NK₃. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called G_q-coupled).

Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as Antiemetic, such as the drug aprepitant.

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Binding The genes and receptor ligands are as follows:

	[[substance P]]
	[[neurokinin A]]
	[[neurokinin B]]

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

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See also

• Substance P
• G protein coupled receptors

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External links

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